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Human Longevity Breakthroughs, Resources, and Websites

Lex DeVille

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Two years ago I posted a lie in the biggest lie I ever believed most of my life thread.

My lie was: That death is certain.

Since then several members have messaged me for more information, and I've posted a few times about the possibilities the future holds and a little bit about current research. Now I think it's time for a thread that brings this to the forefront of some of the brightest minds of this generation and the next.

Most of you - in fact most of the world - has no idea where the human race stands in terms of defeating aging, debilitating diseases, and eventually death. So the purpose of this thread is to enlighten and inform about the Fastlane Scientists & Inventors who work from the shadows to solve a problem most people deny exists.

This thread isn't for personal beliefs. It isn't for politics. The only purpose is to share resources and websites relating to breakthrough longevity research & technology, and to bring you up to speed on what's been going on.

Let's start big...

Meet Dr. Bill Andrews - A Fastlane Research Scientist who has proven reverse aging, has successfully reversed age in mice, and as of August this year, says his company believes they'll completely stop/reverse aging in humans in one year (by 2016). Plus he found a Fastlane way to raise millions per month for research after his investors went broke...


People Unlimited Inc.


Meet Dr. Aubrey de Grey - A Fastlane Research Scientists who built a non-profit company called SENS Foundation that's raised hundreds of millions toward reverse aging research. Dr. de Grey has dedicated his life to solving the world's greatest problem. He's spoken numerous times for TED Talks and is one of the most interesting characters in longevity studies. Here's a video interview with Joe Rogan from earlier this year.


SENS Research Foundation


Meet Dr. Ray Kurzweil - A Fastlane Inventor and Director of Engineering at Google. Dr. Kurzweil invented numerous pieces of life-altering technology, and now he & Google are focused on achieving a concept called The Singularity. Dr. Kurzweil explains that technology is advancing faster and faster and leading to a state of exponential growth. At some point (currently predicted as 2045) artificial intelligence will surpass human intelligence, and man will merge with machine to transcend our current state of being. He discusses all of these concepts in two movies, both of which can be seen on Netflix.


Kurzweil AI


Meet Bill Faloon & Martine Rothblatt - Bill Faloon is the Founder of Life Extension Pharmaceuticals and a Leader in the cryonic preservation & life extension movement. Martine Rothblatt invented Serious XM Satellite Radio in addition to other breakthroughs in medical research. This interview introduces both personalities in addition to the Church of Perpetual Life - the first church openly dedicated to life-extension - and also discusses current events in terms of challenges faced by those interested in living longer.


Church of Perpetual Life


Meet Dr. Max More - President & CEO of Alcor Life Extension Foundation. Alcor is one of 3 Cryopreservation companies in the United States. Cryonics and cryopreservation is a last-resort method of preserving the physical body and brain in the hopes that medical science will one day return them to their former state since we really don't know when a person is truly dead beyond the point of revival. As of now patients have been revived after more than an hour after declared death, and prior to CPR it was believed than anyone who stopped breathing was dead.

Most people believe cryonics is expensive. It's not. I know because I'm signed up and it costs around $34 a month for my insurance policy. Please note that I'm not promoting Alcor or affiliated with them in any way, and my cryonics membership is through one of the other companies.


Alcor Life Extension Foundation


That's enough for today, and a pretty good start. Again, I'm not affiliated with any of these companies nor am I paid for posting this. I just think it's important for young minds with potential to be aware of what's going on in the world that isn't being discussed.

One thing you might notice is that all of the people in the videos above own Fastlane businesses. All of them built companies focused on solving problems, and all focused those efforts on building a better future.

Maybe you care. Maybe you don't. Either way it's new & different, so indulge, enjoy, and feel free to imagine what the future holds. ;)
 
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LifeTransformer

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Very interesting topic.

I remember watching something about this subject a couple years ago, I forget the name of the documentary though, but it was mainly focused on this Doctor (again can't remember his name) and he was talking about the singularity etc too.

Anyone know the documentary I'm talking about? Would like to watch it again.
 

biggeemac

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I certainly hope that our conscientiousness can someday be "dumped" into some cloud infrastructure that we can exist in......sort of like the matrix. Hopefully, we do a little better with the planning and happiness than they did in the matrix. Something that we can live out our wildest fantasies for all eternity, without encroaching, of course, on our fellow virtual mans virtual space.
 

Luffy

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What would longevity mean for the problem of overpopulation? I'm not sure it'd be so public if we were ever successful in this area.
 
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Lex DeVille

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Very interesting topic.

I remember watching something about this subject a couple years ago, I forget the name of the documentary though, but it was mainly focused on this Doctor (again can't remember his name) and he was talking about the singularity etc too.

Anyone know the documentary I'm talking about? Would like to watch it again.

Ray Kurzweil has 2 movies that cover the Singularity in great detail.

The Singularity is Near

Trancendent Man
 

Lex DeVille

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What would longevity mean for the problem of overpopulation? I'm not sure it'd be so public if we were ever successful in this area.

Check out any of Dr. de Grey's videos for in depth answers to this question.
 
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LifeTransformer

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LifeTransformer

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Luffy

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Check out any of Dr. de Grey's videos for in depth answers to this question.
Sucks that there is only $5 million going towards funding something that could change the world and our futures so drastically. Same goes for ocean exploration and the like, humanity sure have their priorities in order.
 
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LynnD5000

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They say Adam lived about 900 years - I wonder what his secret was.....
L
 

obrian

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this is a very interesting topic imagine 50 years from now with all these new technologies and stuff, the possibilities are gonna be endless. i even read this article the other day when these scientist was working on teleportation and they can already transfer some very microscopic tiny particles from part a to point b which is a huge step. they said that in the world of teleportation time doesn't exist and i am like what!!!!!! how is that even possible, but at the end of the day some weird experiments are being taken place each day by these innovative scientists around the world and in my opinion those guys are the heroes, the ones that can make the impossible seem possible, as they usually say these days the sky is not the limit anymore because man have already went to the moon.
 
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Mineralogic

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Two years ago I posted a lie in the biggest lie I ever believed most of my life thread.

My lie was: That death is certain.

Since then several members have messaged me for more information, and I've posted a few times about the possibilities the future holds and a little bit about current research. Now I think it's time for a thread that brings this to the forefront of some of the brightest minds of this generation and the next.

Most of you - in fact most of the world - has no idea where the human race stands in terms of defeating aging, debilitating diseases, and eventually death. So the purpose of this thread is to enlighten and inform about the Fastlane Scientists & Inventors who work from the shadows to solve a problem most people deny exists.

This thread isn't for personal beliefs. It isn't for politics. The only purpose is to share resources and websites relating to breakthrough longevity research & technology, and to bring you up to speed on what's been going on.

Let's start big...

Meet Dr. Bill Andrews - A Fastlane Research Scientist who has proven reverse aging, has successfully reversed age in mice, and as of August this year, says his company believes they'll completely stop/reverse aging in humans in one year (by 2016). Plus he found a Fastlane way to raise millions per month for research after his investors went broke...


People Unlimited Inc.


Meet Dr. Aubrey de Grey - A Fastlane Research Scientists who built a non-profit company called SENS Foundation that's raised hundreds of millions toward reverse aging research. Dr. de Grey has dedicated his life to solving the world's greatest problem. He's spoken numerous times for TED Talks and is one of the most interesting characters in longevity studies. Here's a video interview with Joe Rogan from earlier this year.


SENS Research Foundation


Meet Dr. Ray Kurzweil - A Fastlane Inventor and Director of Engineering at Google. Dr. Kurzweil invented numerous pieces of life-altering technology, and now he & Google are focused on achieving a concept called The Singularity. Dr. Kurzweil explains that technology is advancing faster and faster and leading to a state of exponential growth. At some point (currently predicted as 2045) artificial intelligence will surpass human intelligence, and man will merge with machine to transcend our current state of being. He discusses all of these concepts in two movies, both of which can be seen on Netflix.


Kurzweil AI


Meet Bill Faloon & Martine Rothblatt - Bill Faloon is the Founder of Life Extension Pharmaceuticals and a Leader in the cryonic preservation & life extension movement. Martine Rothblatt invented Serious XM Satellite Radio in addition to other breakthroughs in medical research. This interview introduces both personalities in addition to the Church of Perpetual Life - the first church openly dedicated to life-extension - and also discusses current events in terms of challenges faced by those interested in living longer.


Church of Perpetual Life


Meet Dr. Max More - President & CEO of Alcor Life Extension Foundation. Alcor is one of 3 Cryopreservation companies in the United States. Cryonics and cryopreservation is a last-resort method of preserving the physical body and brain in the hopes that medical science will one day return them to their former state since we really don't know when a person is truly dead beyond the point of revival. As of now patients have been revived after more than an hour after declared death, and prior to CPR it was believed than anyone who stopped breathing was dead.

Most people believe cryonics is expensive. It's not. I know because I'm signed up and it costs around $34 a month for my insurance policy. Please note that I'm not promoting Alcor or affiliated with them in any way, and my cryonics membership is through one of the other companies.


Alcor Life Extension Foundation


That's enough for today, and a pretty good start. Again, I'm not affiliated with any of these companies nor am I paid for posting this. I just think it's important for young minds with potential to be aware of what's going on in the world that isn't being discussed.

One thing you might notice is that all of the people in the videos above own Fastlane businesses. All of them built companies focused on solving problems, and all focused those efforts on building a better future.

Maybe you care. Maybe you don't. Either way it's new & different, so indulge, enjoy, and feel free to imagine what the future holds. ;)


Faloon is doing great work spreading nutrition knowledge for years
 
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Bouncing Soul

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Just one problem with Kurzweil's theory; Moore's Law is either done for microprocessors now, or will be soon. Gordon Moore himself has said this. There's no reviving it at the silicon transistor core level. It requires major breakthroughs in technology, and even the breakthrough stuff we know about in universities doesn't seem particularly promising.

http://singularityhub.com/2015/04/20/looking-ahead-as-moores-law-turns-50-whats-next-for-computing/

I don't think this means the idea of recording stimuli inputs/responses is DOA, but it's not likely to come in the way people who build theories based on extrapolating Moore's law for another several decades predict.

Peter Thiel is another to watch in the longetivity space.
 

Lex DeVille

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Transhumanism on BBC News
A short documentary covering recent updates in transhumanism.



Small Mammal Brain Preservation Contest Won
http://www.brainpreservation.org/small-mammal-announcement/

This article shows an important step in the progress of long-term cryopreservation technologies.
The prize was $100,000 and was very close between 2 companies.
The next contest attempts long-term preservation of large mammallian brains.
This is an incredible breakthrough since...humans are large mammals.

Background and significance

Proponents of cryonics have long sought a technique that could put terminal patients into long-term stasis, the goal being a form of medical time travel in which patients are stabilized against decay with the hope of being revived and cured by future technologies. To that end, over the last two decades cryonics researchers have made progress eliminating ice formation using a technology from mainstream cryobiology called vitrification. Vitrification uses high concentrations of cryoprotectants that allow tissue to solidify during cooling without the formation of ice crystals. When optimally applied, vitrification eliminates damage to cell structures caused by ice formation and has been shown compatible with recovery of biological functioning in small slices of isolated brain tissue. But when applied to whole brains, limitations in diffusibility lead to dramatic shrinkage of the brain’s tissue. Electron microscope images of such brains show dramatic distortions to the delicate neural circuits, and recovery of biological function in whole brains or animals remains far out of reach.

Such difficulties have led a new generation of researchers to focus on a more achievable and demonstrable goal –preservation of brain structure only, without concern for later biological viability. They focus on demonstrating preservation of the delicate pattern of synaptic connections (the “connectome”) which neuroscience contends encodes a person’s memory and identity. Instead of biological revival, these new researchers often envision a future “synthetic revival” comprising nanometer-scale scanning of the preserved brain to serve as the basis for mind uploading.

This shift in focus toward “synthetic” revival opens up new avenues of research and brings the idea of cryonics squarely within the purview of today’s scientific investigation. Hundreds of neuroscience papers have detailed how memory and personality are encoded structurally in synaptic connections, and recent advances in connectome imaging and brain simulation can be seen as a preview of the synthetic revival technologies to come. Until now, the crucial unanswered questions were “How well does cryonics preserve the brain’s connectome?” and “Are there alternatives/modifications to cryonics that might preserve the connectome better and in a manner that could be demonstrated today?” The Brain Preservation Prize was put forward in 2010 to spur research that could definitively answer these questions. Now, five years later, these questions have been answered: As described above, traditional cryonics procedures have not yet been able to demonstrate (to the BPF’s satisfaction) preservation of the connectome, but the newly perfected “Aldehyde-Stabilized Cryopreservation” technique has.

The key breakthrough was the quick perfusion of a deadly chemical fixative (glutaraldehyde) through the brain’s vascular system, rapidly stopping metabolic decay and fixing proteins in place by covalent crosslinks. This stabilized the tissue and, along with other chemicals, enabled cryoprotectants to be perfused at an optimal temperature and rate for the prevention of brain shrinkage. The result was an intact rabbit brain uniformly filled with such a high concentration of cryoprotectants that it could be vitrified solid and stored at -135 degrees Celsius. Electron microscope images from across the rabbit brain showed beautifully preserved neural circuits which look identical to fixation-only control brains.

This result directly answers a main skeptical and scientific criticism against cryonics –that it does not provably preserve the delicate synaptic circuitry of the brain. As such, this research sets the stage for renewed interest within the scientific community, and offers a potential challenge to medical researchers to develop a human surgical procedure based on these successful animal experiments.



Startup to Bring the Dead Back to Life in 30 Years

Seems I'm not the only one who sees opportunity here.

I've had an eye on this company since they first launched.

Glad to see they're still around and growing fast.

http://humaitech.com/
 

OVOvince

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Lol op here I am reading the forum just a little bit before falling asleep and I come across this.

5 minutes later my brain is thinking about how earth will be overpopulated if everyone lives forever and we will have to use Elon Musks' space x to colonize Mars or create some sort of artificial habitat in space or something hahaha
 
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Lex DeVille

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Lol op here I am reading the forum just a little bit before falling asleep and I come across this.

5 minutes later my brain is thinking about how earth will be overpopulated if everyone lives forever and we will have to use Elon Musks' space x to colonize Mars or create some sort of artificial habitat in space or something hahaha

Same objection most people have the first time they come across the concept.

Thing is the earth is already overpopulated. Yet we live here and don't seem to mind.

People aren't stupid. We come up with new ways to make it work.

We will colonize Mars. It's not that far away. The news regularly mentions the upcoming mission.

http://www.nasa.gov/content/nasas-journey-to-mars/

This video shows how we can potentially reach Mars in 3 days.


Here's a 52 page white paper to go with it entitled "A Roadmap To Interstellar Flight."

http://www.deepspace.ucsb.edu/wp-content/uploads/2015/04/A-Roadmap-to-Interstellar-Flight-15-h.pdf

There's really no reason for humans to stay on Earth long-term.

We've discovered plenty of places that may be habitable. Some not that far away.
 

OVOvince

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Same objection most people have the first time they come across the concept.

Thing is the earth is already overpopulated. Yet we live here and don't seem to mind.

People aren't stupid. We come up with new ways to make it work.

We will colonize Mars. It's not that far away. The news regularly mentions the upcoming mission.

http://www.nasa.gov/content/nasas-journey-to-mars/

This video shows how we can potentially reach Mars in 3 days.


Here's a 52 page white paper to go with it entitled "A Roadmap To Interstellar Flight."

http://www.deepspace.ucsb.edu/wp-content/uploads/2015/04/A-Roadmap-to-Interstellar-Flight-15-h.pdf

There's really no reason for humans to stay on Earth long-term.

We've discovered plenty of places that may be habitable. Some not that far away.
I knew it can be done but wow I didn't know about how quick


Cool
 

7.62x51

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I think that minduploading is a flawed concept. A digital copy of yourself is just that, a copy, it's not the original.

In order to reach true immortality, we need to be able to preserve the human brain.

It was thought that every 7-10 years all the cells in your body are replaced but new research has shown that neurons in your cerebral cortex are never replaced.
_8300594.png


In order to preserve or maintain a complex system, one needs to understand how the components interact with each other.

Before we solve aging, we'll need to solve intelligence.

Personally believe that this generation or the next will solve intelligence and then the generation that follows will use the advanced AI + full understanding of the brain to reach real immortality.
 
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Lex DeVille

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I think that minduploading is a flawed concept. A digital copy of yourself is just that, a copy, it's not the original.

In order to reach true immortality, we need to be able to preserve the human brain.

It was thought that every 7-10 years all the cells in your body are replaced but new research has shown that neurons in your cerebral cortex are never replaced.
_8300594.png


In order to preserve or maintain a complex system, one needs to understand how the components interact with each other.

Before we solve aging, we'll need to solve intelligence.

Personally believe that this generation or the next will solve intelligence and then the generation that follows will use the advanced AI + full understanding of the brain to reach real immortality.

I agree that more learning is needed in order for us to advance to any stage of uploading.
We don't need to fully understand every aspect of intelligence to accomplish this though.
AI will pick up where humans leave off long before we fully understand ourselves completely.

Regarding solving aging, the gene responsible for aging has already been identified.
Aging has been fully reversed in rats by Bill Andrews and his team, as indicated in the very first video above.

Regarding the issue of a digital copy not being you, how do you define you?

If you define "you" as something you can never know or experience (the experiencer / observer) then the copy is no more "you" than you are "you" right now. That means it is also no less "you" than you are "you" right now.

If you define "you" as your body + your memories + your experiences, knowledge etc, then there is no difference if the only thing that changes is your physical body.

Same memories + Same experiences + Same everything except physical body = "You" by this definition and you wouldn't know any different beyond perhaps noticing your body is different.

This is moving heavily into philosophical territory, and the purpose of this thread is only to provide resources regarding life extension and longevity, and not to discuss immortality, so I won't go any deeper into this for now.

Regardless of our beliefs about what is possible right now, we can't predict the future.
So the best we can do is remain optimistic, much like we do in our business pursuits.

We use what is useful.
Pessimism is rarely useful.
 

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I think that minduploading is a flawed concept. A digital copy of yourself is just that, a copy, it's not the original.

This in so many ways. People seem to think our consciousness is like an operating system (Windows, Linux, OSX, etc), that it's just a piece of software running on hardware. In theory, we can take that software and place it in a virtual environment and it will work the same. The reality is our consciousness is more like firmware, it's directly tied into our bodies, and even more, physical changes within our body impact how our consciousness work. I'm thinking of phantom limbs. Instances where the software in the brain has modified itself in response to the loss of limb and literally changed the hardware.

Personally believe that this generation or the next will solve intelligence and then the generation that follows will use the advanced AI + full understanding of the brain to reach real immortality.

I am extremely skeptical of the notion of true, or advanced, AI. A big element of intelligence is the ability to step outside of a system and reason about it. Humans possess the ability to look at themselves objectively since we are conscious of our conscious (and no one knows why). Computer are machines, they will only do EXACTLY what you tell them to do. Watson and AlphaGO took advantage of the facts that the systems they were in had well defined rules and they could quickly compute all permutations and choose the one that had the highest statistical success. I don't want to take away from the achievements, just point out we are very very far away from Skynet.
 

Delmania

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Regarding the issue of a digital copy not being you, how do you define you?

Perspective and experience. You upload your conscious and then go on with your life. Is your awareness now in both your body AND the computer? When your body dies, does your perspective change back to the computer? Do you watch yourself die without interruption to your consciousness?
 
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Lex DeVille

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Perspective and experience. You upload your conscious and then go on with your life. Is your awareness now in both your body AND the computer? When your body dies, does your perspective change back to the computer? Do you watch yourself die without interruption to your consciousness?

When the conscious (mind) is uploaded a body is no longer required, though most experts suspect the body will merge with machine. It is certainly complex to consider; however, this is a stage of evolution.

It's not hard to imagine our conscious could be in more than one place at once assuming uploading is what occurs.

I can't say what would happen when the body dies, assuming the body dies at all, without getting a bit too philosophical and potentially tip toeing into religious beliefs.
 

Delmania

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When the conscious (mind) is uploaded a body is no longer required, though most experts suspect the body will merge with machine. It is certainly complex to consider; however, this is a stage of evolution.

It's not hard to imagine our conscious could be in more than one place at once assuming uploading is what occurs.

I can't say what would happen when the body dies, assuming the body dies at all, without getting a bit too philosophical and potentially tip toeing into religious beliefs.

Yes, we're getting away from longevity and into the "brain in a vat" and "the universe is a simulation" theories. Fascinating stuff, but definitely subjective and rabbit holes.
 

7.62x51

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I am extremely skeptical of the notion of true, or advanced, AI. A big element of intelligence is the ability to step outside of a system and reason about it. Humans possess the ability to look at themselves objectively since we are conscious of our conscious (and no one knows why). Computer are machines, they will only do EXACTLY what you tell them to do. Watson and AlphaGO took advantage of the facts that the systems they were in had well defined rules and they could quickly compute all permutations and choose the one that had the highest statistical success. I don't want to take away from the achievements, just point out we are very very far away from Skynet.

Reaching human level AI means we have systems that are at least as widely adaptable and efficient as the human neocortex in regards to how they process information.

This ability in of itself will not lead to an autonomous system with survival instincts (nor is that the goal). But it will allow us to solve entirely new categories of problems that would otherwise be impractical.

We only have a small part of the intelligence puzzle figured out and we can already use it to make things like AlphaGO and self driving cars.
 

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"Society never advances. It recedes as fast on one side as it gains on the other. It undergoes continual changes; it is barbarous, it is civilized, it is christianized, it is rich, it is scientific; but this change is not amelioration. For every thing that is given, something is taken."

-Emerson
 
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Lex DeVille

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"Society never advances. It recedes as fast on one side as it gains on the other. It undergoes continual changes; it is barbarous, it is civilized, it is christianized, it is rich, it is scientific; but this change is not amelioration. For every thing that is given, something is taken."

-Emerson

Not sure why you felt it necessary to post the words of a dead man in a thread about longevity.

Please keep your personal beliefs out of this thread.

This thread is for resources for those interested in longevity.

Not the convictions of those stuck in the past.
 
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Kallin Trotman

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Not sure why you felt it necessary to post the words of a dead man in a thread about longevity.

Please keep your personal beliefs out of this thread.

This thread is for resources for those interested in longevity.

Not the convictions of those stuck in the past.

I apologise for my ignorance of my knowledge that this thread was for resources only, I assumed that discussion was welcome. While none of my personal beliefs were stated I am unsure as to why you would be negative towards a perspective that is closely related to the subject of the thread.
 

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