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NOTABLE! Human Longevity Breakthroughs, Resources, and Websites

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ravenspear

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If anyone of you are not working out that is the number one thing you can do for health imo.

This is the third time I've fallen off the wagon a bit since I started a few years ago but I'm getting back to it regularly now and I feel so much better.

This is the 2nd or third time that a predictable pattern has happened. Every time I haven't squatted heavy for a certain time and I come back to it, I get sick after my first big work out.

Why is this? The demand exercise places on the body is HARD, especially compound lifts. But the benefit you gain when you regularly do these is that your body responds by becoming stronger and more resistant to disease, inside and out. I feel like a superman every time I crush a hard workout once I'm on the path regularly, and it gives me so much energy, power, clear thought, determination, and peace of mind.

The 2nd best thing is to be hungry every once in a while, this clears away a lot of junk in the body that can build up if your nutrition is always met by food every few hours.

The vast majority of general health problems that afflict the general population like heart disease, most cancers, etc are fixed by doing just these two.
 

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MHP368

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Heres an interesting new pharma

Just had positive phase 3 results (seeking fda approval)

Its for a rare degenerative nerve disease (runs in my family)

Heres the kicker though ill ELI5 how this drug works. Its telling the dna in your cells mitochondria (the cells power house) to create more proteins associated with antioxidant activity while simultaneously telling it to stop producing proteins that are inflammatory.

So instead of taking vitamin c and tumeric and receiving anti oxidant and anti inflammatory effects endogenously (from outside the body) , its forcing the activity upstream right at the cellular powerhouse.

The fact that a medicine exists to do this , is proven and is seeking fda approval is nothing short of a medical technology hail mary.

The amount of associated discoveries and followup drugs and supplements that will be available now that a drug pathway to get this to work has been validated is nothing short of stunning.

Were a real step , a real empirically tested scientifically sound step closer to an honest to god anti aging pill. If you can modify the pathway for a few proteins coding information with this precision it opens up just entire avenues that were science fiction not ten years ago.
 

Lex DeVille

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Bill Faloon of Life Extension is live now with the Perpetual Life Church Life talking about the latest and greatest in reverse aging and life extension.

 

Lex DeVille

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Ageing in humans reversed with hyperbaric oxygen therapy​


Scientists, led by Yafit Hachmo, from the Research and Development Unit, Shamir Medical Center, Tzrifin, Israel, turned back the human clock for 35 adults aged 64 and older by reversing two key areas of the body thought responsible for the frailty and ill-health that comes with growing older. Protective caps at the ends of chromosomes, known as telomeres, shorten, causing DNA to become damaged and cells to stop replicating as people age. At the same time, senescent cells build up in the body, preventing regeneration.

Increasing telomere length and getting rid of senescent cells is the focus of anti-ageing research, with drugs being developed to target those areas, The Telegraph reported.

The 35 patients were repeatedly given pure oxygen in a hyperbaric chamber, which increased the length of their telomeres by 20%, a feat that has never been achieved before.

Scientists said the growth may mean that the telomeres of trial participants were now as long as they had been 25 years earlier.

The therapy also reduced senescent cells by up to 37%, enabling new healthy cells to regrow
. Animal studies have shown that removing senescent cells extends remaining life by more than 33%.

This may be a solid business idea for someone in the near future.
 
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MHP368

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Ageing in humans reversed with hyperbaric oxygen therapy​




This may be a solid business idea for someone in the near future.

Tony Robbins did a long hyperbaric treatment for his spine and mercury poison at one point (iirc he went to australia for it)

I wonder what the margins on a fancy health spa are?

Seems like something that wouldn't scale well since youd need the boujie customer base.
 

Seeker

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tl;dr: Has anybody a good and trustworthy source for NMN?

After reading David Sinclairs Lifespan book I'm very tempted to try NMN. If you are interested in what the author takes today, this website provides a good write-up with sources:
David Sinclair Supplements - What He Takes & Where to Buy - NMN, Resveratrol & Metformin

Unfortunately it seems to be very difficult to find a good source that meets my demands:
- capsule form
- third party tested for purity AND absence of heavy metals
- micronized for better bio avialability
- under 4$ / gramm
- trustworthy manufacturer

I now spent more than 5 hours trying to find that. Haven't found it on Amazon. Many other sites google offers seem to be shady or too expensive. effePharm from Shanghai seemed promising. But after a quick research it turned out, that the building on their website was just a stock photo and is not to be found on google maps sattelite pictures. That is not trustworthy to me. Nadiol doesn't seem to test for heavy metals and is not mentioned if it's micronized (so I assume it's not - still wating for a reply from customer service). Some german webshops are so laughably bad that I consider making a better one myself.

@Lex DeVille @LifeTransformer
So if you take NMN, where did you get yours from?

And did you test the results using a horvard clock analysis?
 
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Lex DeVille

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Bill Falloon - Summary of Recent Longevity Research Progress
 

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Lex DeVille

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Lex DeVille

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Dr. David Sinclair is taking applications for his new research to determine your biological age. (Free to join)

Dr. Sinclair | Longevity + Aging Expert

And if you go through this link you can sign up and bump me up on the list at the same time. :)
 

Lex DeVille

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Dr. David Sinclair is taking applications for his new research to determine your biological age. (Free to join)

Dr. Sinclair | Longevity + Aging Expert

And if you go through this link you can sign up and bump me up on the list at the same time. :)

I've dropped from #66,000 to #22 on the list. Maybe I'll become a research guinea pig sooner than expected.
 

Lex DeVille

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Dr. Harold Katcher - Chief Scientific Officer at Yuvan Research Inc. - Discusses "E5" - Another Potential Age Reversal Breakthrough Showing Massive Success in Mice


This was posted 2 days ago. In the video, he also discusses moving into human trials and aiming for global distribution within the human population within 2 years. Apparently, the ingredients for E5 are widely available, making fast distribution possible once it is approved for use in humans.

I'm paraphrasing, but my understanding is that it isn't a question of whether or not E5 works at this point. The one unknown is how many times it will work. Currently, the mice seem to be doing well after 3 rounds of treatments. They're in their 3rd year of life (the longest is 4 for lab mice according to the video).

Also, Brent Nally's (the video host) YouTube channel is all about longevity, and he has had numerous interviews with people like Dr. Bill Andrews, Dr. Sinclair, and Dr. De Grey. I only came across it today, but it looks like a valuable resource for keeping up with the latest breakthroughs.

 
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Lex DeVille

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Lex DeVille

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any thoughts?

I don't eat fast food at all. Rarely eat at restaurants. Most use low-quality ingredients that can be sold at scale.

There are some small restaurants here that get their ingredients from local farms that I trust. So I'll eat at those places if I feel like dining out.

Mostly, I get food from local farms or Natural Grocers and cook it myself in real butter, never vegetable oil.

I did eat donuts a couple of times this year from a regular donut shop. My body got so inflamed within a week (both times) that it looked like I'd gained 20lbs.
 

thechosen1

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Jeff Bezos Funds Antiaging Biotech Startup with $270m
People hate on everything this man does but I'm actually really happy and excited that he's focusing on things like longevity and space exploration.

Innovation doesn't just happen!
 

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